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Phentermine

Available in: Tablets, capsules
Drug Class: Appetite suppressant
Not available over-the-counter
Not available as Generic

Brand Names

Adipex-P, Fastin, Obe-Mar, Obe-Nix, Obephen, Obytrim, Panshape M, Phentercot, Phentride Caplets, Phentrol, Phentrol-2, Phentrol-4, Phentrol-5, T-Diet, Ionamin

Side Effects

Serious: Confusion or mental depression, skin rash or hives, high blood pressure, sore throat and fever, unusual bleeding or bruising. Call your doctor immediately.
Common: Irritability, nervousness, restlessness, insomnia.
Less Common: Blurred vision, change in sexual desire, constipation or diarrhea, difficult or painful urination, dizziness, lightheadedness, drowsiness, dry mouth, rapid heartbeat, increased urination, headache, increased sweating, nausea or vomiting, stomach cramps, unpleasant taste in the mouth.

Principal Uses

To suppress appetite in obese patients. It should be used in conjunction with a strict diet and should not be prescribed as the sole method for achieving weight loss.

How the Drug Works

Researchers believe that the appetite-control center for the body may be found in a part of the brain called the hypothalamus. Phentermine probably affects the transmission of nerve impulses in this area.

Dosage

15 to 37.5 mg once a day.

Onset of Effect

Within 1 hour.

Duration of Action

12 to 14 hours.

Dietary Advice

Phentermine can be taken before breakfast or 1 to 2 hours after breakfast.

Storage

Store in a tightly sealed container away from heat and direct light.

If You Miss a Dose

Take it as soon as you remember. If it is near the time for the next dose, skip the missed dose and return to your regular dosage schedule. Do not double the next dose.

Stopping the Drug

Take as prescribed for the full treatment period, even if you begin to observe favorable results before the scheduled end of therapy.

Prolonged Use

Prolonged use of phentermine may result in drug tolerance or occasionally drug dependence.

Precautions

Over 60 - Adverse reactions may be more likely and more severe in older patients, especially when taken in combination with drugs that act on the central nervous system.
Driving and Hazardous Work - Do not drive or engage in hazardous work until you determine how the medicine affects you.
Alcohol - Avoid alcohol.
Pregnancy - Phentermine has not been shown to cause birth defects in humans. Before you take this drug, tell your doctor if you are pregnant or planning to become pregnant.
Breast Feeding - Phentermine may pass into breast milk; caution is advised. Consult your doctor for advice.
Infants and Children - Not recommended for use by children under age 16.
Special Concerns - After you stop taking this drug, your body may need time to adjust. Phentermine may affect blood sugar levels; consult your doctor if you have any concern. Notify your doctor if you experience mental depression, nausea or vomiting, unusual fatigue, or trembling after you stop taking phentermine. Before you have medical or dental treatment, be sure to tell your doctor or dentist that you are taking phentermine.

Overdose

Symptoms: Stomach cramps, severe diarrhea, fever, hallucinations, unusual high or low blood pressure, irregular heartbeat, severe nausea or vomiting, feeling of panic, restlessness, tremor.
What to Do: An overdose of phentermine is unlikely to be life-threatening. However, if someone takes a much larger dose than recommended, call your doctor, emergency medical services (EMS), or the nearest poison control center immediately.

Drug Interactions

The following drugs may interact with phentermine. Consult your doctor for specific advice if you are taking amantadine, amphetamines, chlophenadiol, medicine for asthma, colds, sinus problems, or allergies, methyl-phenidate, nabilone, pemoline, selective serotonin reuptake inhibitors (SSRIs), or MAO inhibitors.

Food Interactions

Avoid caffeine-containing beverages.

Disease Interactions

Caution is advised when taking phentermine. Consult your doctor if you have any of the following: a history of drug or alcohol abuse, diabetes, epilepsy, glaucoma, heart disease, blood vessel disease, high blood pressure, an overactive thyroid, or kidney disease.